VARS SOD (formerly known as SOD Booster)

What VARS® SOD Does For You

SOD is the body’s most powerful endogenous antioxidant enzyme — and VARS® SOD delivers it in a validated, bioavailable form with synergistic cofactors that amplify its protective effects throughout the body.

• Unmatched Antioxidant Support — Superoxide Dismutase is the primary enzyme responsible for neutralizing superoxide radicals — the most abundant and reactive free radicals produced by cellular metabolism. SOD converts superoxide into hydrogen peroxide, which is then safely neutralized by other antioxidant enzymes. No dietary antioxidant operates at this level of cellular protection.
• Stress Relief & Improved Well-being — Oxidative stress is a major driver of physical and psychological stress responses. By reducing the cellular burden of superoxide radicals, SOD helps lower the physiological stress load, supporting a greater sense of calm, resilience, and overall well-being.
• Anti-Inflammatory Properties — Superoxide radicals are key initiators of the inflammatory cascade. SOD neutralizes superoxide before it can trigger downstream inflammatory signaling, helping reduce chronic low-grade inflammation that underlies many modern health conditions.
• Enhanced Sleep Quality — Oxidative stress disrupts circadian rhythm regulation and melatonin production. By reducing oxidative burden, SOD supports healthier sleep architecture, deeper rest, and more consistent sleep-wake cycles.
• Immune System Support — SOD plays a critical role in immune cell function, protecting immune cells from the oxidative damage they generate during immune responses. Optimal SOD activity supports a more effective and balanced immune system.
• Defends Your Cells — SOD is the first line of intracellular antioxidant defense, protecting mitochondria, DNA, and cellular membranes from superoxide-induced damage that drives aging and disease.
• Reduces Inflammation — By intercepting superoxide at the source, SOD prevents the formation of peroxynitrite and other highly reactive nitrogen species that amplify inflammatory damage in tissues.
• Restores Balance — Vitamin E (Mixed Tocopherols) and Manganese Gluconate work synergistically with SOD — Manganese is an essential cofactor for mitochondrial SOD (SOD2), and Vitamin E protects cell membranes from lipid peroxidation, extending the antioxidant protection throughout the cell.

What’s Inside VARS® SOD

Serving Size: 1 Capsule | Servings Per Container: 60

SOD 2 and 3 Blend (Superoxide Dismutase 5000 IU) — 10mg

Superoxide Dismutase (SOD) is a family of metalloenzymes that catalyze the dismutation of superoxide radicals into oxygen and hydrogen peroxide. VARS® SOD contains a blend of SOD isoforms 2 and 3 — the mitochondrial and extracellular forms — providing comprehensive protection both inside and outside the cell. Each capsule delivers 5000 IU of SOD activity, a clinically meaningful dose for systemic antioxidant support.

The challenge with oral SOD supplementation has historically been bioavailability — SOD is a large protein that can be degraded in the digestive tract. The VARS® formulation addresses this with a delivery system designed to protect SOD through digestion and maximize its systemic availability, consistent with the VARS® (Validated Absorbable, Reduced Stable) standard.

Vitamin E (Mixed Tocopherols) — 5mg (55% DV)

Mixed Tocopherols provide the full spectrum of Vitamin E activity — alpha, beta, gamma, and delta tocopherols — rather than the isolated alpha-tocopherol found in most supplements. Vitamin E is a fat-soluble antioxidant that protects cell membranes from lipid peroxidation, working synergistically with SOD to provide comprehensive antioxidant coverage across both aqueous and lipid cellular compartments.

Manganese Gluconate — 100mcg (22% DV)

Manganese is an essential cofactor for SOD2 (mitochondrial superoxide dismutase) — without adequate manganese, SOD2 cannot function. Manganese Gluconate is a highly bioavailable chelated form of manganese that ensures the SOD2 enzyme has the cofactor it needs to operate at full capacity within the mitochondria, where the majority of cellular superoxide is produced.

Other Ingredients

Rice bran flour, vegetable capsule (hypermellose/HPMC, purified water). Made in the USA.

Directions for Use

Take 1 capsule daily as directed on the product label. VARS® SOD is designed for consistent daily use to maintain optimal antioxidant enzyme activity over time.

• Take 1 capsule per serving
• Can be taken with or without food
• Best taken in the morning to support antioxidant defense and energy throughout the day
• Store in a cool, dry place away from direct sunlight and heat
• Keep out of reach of children
• Do not exceed recommended serving size

Pro Tips:

• SOD activity naturally declines with age — consistent daily supplementation is the most effective strategy for maintaining optimal cellular antioxidant defense
• Pairs powerfully with VARS® Liposomal Glutathione — glutathione neutralizes the hydrogen peroxide produced by SOD’s action on superoxide, completing the antioxidant cycle and amplifying the protective effect of both supplements
• Pairs well with VARS® Liposomal Vitamin C for comprehensive multi-layer antioxidant coverage across all cellular compartments
• Avoid excessive alcohol and smoking, which dramatically increase superoxide production and deplete SOD activity

Frequently Asked Questions

Q: What is Superoxide Dismutase and why is it important?
A: Superoxide Dismutase (SOD) is the body’s most powerful endogenous antioxidant enzyme. It neutralizes superoxide radicals — the most abundant and reactive free radicals produced by normal cellular metabolism — converting them into hydrogen peroxide, which is then safely neutralized by other antioxidant enzymes. SOD is the first line of intracellular antioxidant defense and is critical for protecting mitochondria, DNA, and cellular membranes from oxidative damage.

Q: What is the difference between SOD2 and SOD3?
A: SOD2 (manganese SOD) is located in the mitochondria — the primary site of superoxide production in the cell. SOD3 (extracellular SOD) is found in the spaces between cells and in the bloodstream, protecting tissues from extracellular oxidative damage. VARS® SOD contains both isoforms, providing comprehensive antioxidant protection both inside and outside the cell.

Q: Why does VARS® SOD include Vitamin E and Manganese?
A: Manganese is an essential cofactor for SOD2 — without it, the mitochondrial SOD enzyme cannot function. Vitamin E (Mixed Tocopherols) protects cell membranes from lipid peroxidation, working synergistically with SOD to provide antioxidant coverage in the lipid compartments of the cell that SOD alone cannot reach. Together, these three ingredients provide a complete, synergistic antioxidant system.

Q: How is VARS® SOD different from other SOD supplements?
A: VARS® SOD uses a validated delivery system designed to protect SOD through the digestive tract and maximize systemic bioavailability — consistent with the VARS® (Validated Absorbable, Reduced Stable) standard. It also includes both SOD2 and SOD3 isoforms and synergistic cofactors, making it a more complete antioxidant system than single-isoform SOD supplements.

Q: How long before I notice results?
A: Many users notice improvements in energy, stress resilience, and sleep quality within 2–4 weeks of consistent daily use. Anti-inflammatory and cellular protection benefits build over time with continued supplementation.

Q: How many capsules are in a bottle?
A: 60 capsules — a 30+ day supply at the recommended 1 capsule per day.

Q: When will my order ship?
A: Orders ship Monday through Friday with a 3 business day processing time. You will receive an email notification when your order ships.

Allergen Information: VARS® SOD contains Vitamin E (Mixed Tocopherols) derived from soy or sunflower sources. If you have any food allergies, sensitivities, or are taking blood thinners or other medications, please consult your healthcare provider before use. Keep out of reach of children.